Identification of targetable BRAF ΔN486_P490 variant by whole-genome sequencing leading to dabrafenib-induced remission of a BRAF-mutant pancreatic adenocarcinoma

The tumor genome of a patient with advanced pancreatic cancer was sequenced to identify potential therapeutic targetable mutations after standard of care failed to produce any significant overall response. Matched tumor-normal whole-genome sequencing revealed somatic mutations in BRAF, TP53, CDKN2A,...

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Dades bibliogràfiques
Publicat a:Cold Spring Harb Mol Case Stud
Autors principals: Wrzeszczynski, Kazimierz O., Rahman, Sadia, Frank, Mayu O., Arora, Kanika, Shah, Minita, Geiger, Heather, Felice, Vanessa, Manaa, Dina, Dikoglu, Esra, Khaira, Depinder, Chimpiri, A. Rao, Michelini, Vanessa V., Jobanputra, Vaidehi, Darnell, Robert B., Powers, Scott, Choi, Minsig
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2019
Matèries:
Rapid Cancer Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913137/
https://ncbi.nlm.nih.gov/pubmed/31519698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a004424
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