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Predicting associations among drugs, targets and diseases by tensor decomposition for drug repositioning

BACKGROUND: Development of new drugs is a time-consuming and costly process, and the cost is still increasing in recent years. However, the number of drugs approved by FDA every year per dollar spent on development is declining. Drug repositioning, which aims to find new use of existing drugs, attra...

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Veröffentlicht in:BMC Bioinformatics
Hauptverfasser: Wang, Ran, Li, Shuai, Cheng, Lixin, Wong, Man Hon, Leung, Kwong Sak
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912989/
https://ncbi.nlm.nih.gov/pubmed/31839008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-3283-6
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