Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors

[Image: see text] The ability of G protein-coupled receptor (GPCR) kinases (GRKs) to regulate desensitization of GPCRs has made GRK2 and GRK5 attractive targets for treating heart failure and other diseases such as cancer. Although advances have been made toward developing inhibitors that are select...

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Bibliografiska uppgifter
I publikationen:ACS Med Chem Lett
Huvudupphovsmän: Rowlands, Rachel A., Cato, M. Claire, Waldschmidt, Helen V., Bouley, Renee A., Chen, Qiuyan, Avramova, Larisa, Larsen, Scott D., Tesmer, John J. G., White, Andrew D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2019
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912873/
https://ncbi.nlm.nih.gov/pubmed/31857838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00365
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