Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis

Tankyrase is a poly(ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors suppress the degradation of AXIN protein, a negative regulator of the canonical Wnt pathway, they effectively act as Wnt inhibitors. Small molecule tankyrase inhibit...

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Vydáno v:Bone
Hlavní autoři: Fujita, Shunichi, Mukai, Tomoyuki, Mito, Takafumi, Kodama, Shoko, Nagasu, Akiko, Kittaka, Mizuho, Sone, Teruki, Ueki, Yasuyoshi, Morita, Yoshitaka
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912859/
https://ncbi.nlm.nih.gov/pubmed/29055830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2017.10.017
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