Functional significance of U2AF1 S34F mutations in lung adenocarcinomas

The functional role of U2AF1 mutations in lung adenocarcinomas (LUADs) remains incompletely understood. Here, we report a significant co-occurrence of U2AF1 S34F mutations with ROS1 translocations in LUADs. To characterize this interaction, we profiled effects of S34F on the transcriptome-wide distr...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Esfahani, Mohammad S., Lee, Luke J., Jeon, Young-Jun, Flynn, Ryan A., Stehr, Henning, Hui, Angela B., Ishisoko, Noriko, Kildebeck, Eric, Newman, Aaron M., Bratman, Scott V., Porteus, Matthew H., Chang, Howard Y., Alizadeh, Ash A., Diehn, Maximilian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911043/
https://ncbi.nlm.nih.gov/pubmed/31836708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13392-y
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