Peptide hormone ELABELA enhances extravillous trophoblast differentiation, but placenta is not the major source of circulating ELABELA in pregnancy

Preeclampsia is a frequent gestational hypertensive disorder with equivocal pathophysiology. Knockout of peptide hormone ELABELA (ELA) has been shown to cause preeclampsia-like symptoms in mice. However, the role of ELA in human placentation and whether ELA is involved in the development of preeclam...

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Udgivet i:Sci Rep
Main Authors: Georgiadou, Danai, Boussata, Souad, Ranzijn, Willemijn H. M., Root, Leah E. A., Hillenius, Sanne, bij de Weg, Jeske M., Abheiden, Carolien N. H., de Boer, Marjon A., de Vries, Johanna I. P., Vrijkotte, Tanja G. M., Lambalk, Cornelis B., Kuijper, Esther A. M., Afink, Gijs B., van Dijk, Marie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911039/
https://ncbi.nlm.nih.gov/pubmed/31836787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55650-5
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