miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

In type 1 diabetes, the appearance of islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. While T cells play a major role in the destruction of pancreatic beta cells, molecular underpinnings promoting aberrant T cell activation remain poor...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Scherm, Martin G., Serr, Isabelle, Zahm, Adam M., Schug, Jonathan, Bellusci, Saverio, Manfredini, Rossella, Salb, Victoria K., Gerlach, Katharina, Weigmann, Benno, Ziegler, Anette-Gabriele, Kaestner, Klaus H., Daniel, Carolin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910913/
https://ncbi.nlm.nih.gov/pubmed/31836704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13587-3
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