Impact of the Baloxavir-Resistant Polymerase Acid I38T Substitution on the Fitness of Contemporary Influenza A(H1N1)pdm09 and A(H3N2) Strains

BACKGROUND: Baloxavir is a cap-dependent inhibitor of the polymerase acid (PA) protein of influenza viruses. While appearing virologically superior to oseltamivir, baloxavir exhibits a low barrier of resistance. We sought to assess the impact of the common baloxavir-resistant I38T PA substitution on...

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Vydáno v:J Infect Dis
Hlavní autoři: Checkmahomed, Liva, M’hamdi, Zeineb, Carbonneau, Julie, Venable, Marie-Christine, Baz, Mariana, Abed, Yacine, Boivin, Guy
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910874/
https://ncbi.nlm.nih.gov/pubmed/31419295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiz418
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