Rho-associated kinase and zipper-interacting protein kinase, but not myosin light chain kinase, are involved in the regulation of myosin phosphorylation in serum-stimulated human arterial smooth muscle cells

Myosin regulatory light chain (LC(20)) phosphorylation plays an important role in vascular smooth muscle contraction and cell migration. Ca(2+)/calmodulin-dependent myosin light chain kinase (MLCK) phosphorylates LC(20) (its only known substrate) exclusively at S19. Rho-associated kinase (ROCK) and...

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Bibliographic Details
Published in:PLoS One
Main Authors: Deng, Jing-Ti, Bhaidani, Sabreena, Sutherland, Cindy, MacDonald, Justin A., Walsh, Michael P.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910671/
https://ncbi.nlm.nih.gov/pubmed/31834925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226406
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