miR-140 Attenuates the Progression of Early-Stage Osteoarthritis by Retarding Chondrocyte Senescence

Osteoarthritis (OA) is a major cause of joint pain and disability, and chondrocyte senescence is a key pathological process in OA and may be a target of new therapeutics. MicroRNA-140 (miR-140) plays a protective role in OA, but little is known about its epigenetic effect on chondrocyte senescence....

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Publicat a:Mol Ther Nucleic Acids
Autors principals: Si, Hai-bo, Yang, Ti-min, Li, Lan, Tian, Mei, Zhou, Li, Li, Dai-ping, Huang, Qiang, Kang, Peng-de, Yang, Jing, Zhou, Zong-ke, Cheng, Jing-qiu, Shen, Bin
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6909049/
https://ncbi.nlm.nih.gov/pubmed/31790972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.10.032
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