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Discovery of Novel Doxorubicin Metabolites in MCF7 Doxorubicin-Resistant Cells
Doxorubicin (DOX) is metabolized to a variety of metabolites in vivo, which has been shown to be associated with cardiotoxicity. We speculate that metabolic processes are also present in tumor cells. A LC-MS/MS method was developed to detect intracellular metabolites. Drug resistant tumor cells with...
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| Publicat a: | Front Pharmacol |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Media S.A.
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6909010/ https://ncbi.nlm.nih.gov/pubmed/31866863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01434 |
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