Discovery of Novel Doxorubicin Metabolites in MCF7 Doxorubicin-Resistant Cells

Doxorubicin (DOX) is metabolized to a variety of metabolites in vivo, which has been shown to be associated with cardiotoxicity. We speculate that metabolic processes are also present in tumor cells. A LC-MS/MS method was developed to detect intracellular metabolites. Drug resistant tumor cells with...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: Wang, Xu, Hui, Renjie, Chen, Yun, Wang, Wentao, Chen, Yujiao, Gong, Xiaohai, Jin, Jian
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6909010/
https://ncbi.nlm.nih.gov/pubmed/31866863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01434
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