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Engineering enzymatic assembly lines to produce new antibiotics

Numerous important therapeutic agents, including widely-used antibiotics, anti-cancer drugs, immunosuppressants, agrochemicals and other valuable compounds, are produced by microorganisms. Many of these are biosynthesised by modular enzymatic assembly line polyketide synthases, non-ribosomal peptide...

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Pubblicato in:Curr Opin Microbiol
Autori principali: Bozhüyük, Kenan AJ, Micklefield, Jason, Wilkinson, Barrie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Current Biology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908967/
https://ncbi.nlm.nih.gov/pubmed/31743841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mib.2019.10.007
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