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Nectin-4 cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, enhancing their activation and DNA synthesis

Nectin-4 cell adhesion molecule and ErbB2 tyrosine kinase receptor are upregulated in many cancers, including breast cancer, and promote cancer cell proliferation and metastasis. Using human breast cancer cell lines T47D and SUM190-PT, in which both nectin-4 and ErbB2 were upregulated, we showed her...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Kedashiro, Shin, Sugiura, Ayumu, Mizutani, Kiyohito, Takai, Yoshimi
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908695/
https://ncbi.nlm.nih.gov/pubmed/31831814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55460-9
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