Synthesis and preclinical validation of novel P2Y1 receptor ligands as a potent anti-prostate cancer agent

Purinergic receptor is a potential drug target for neuropathic pain, Alzheimer disease, and prostate cancer. Focusing on the structure-based ligand discovery, docking analysis on the crystal structure of P2Y(1) receptor (P2Y(1)R) with 923 derivatives of 1-indolinoalkyl 2-phenolic compound is perform...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Le, Hien Thi Thu, Rimpilainen, Tatu, Konda Mani, Saravanan, Murugesan, Akshaya, Yli-Harja, Olli, Candeias, Nuno R., Kandhavelu, Meenakshisundaram
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908675/
https://ncbi.nlm.nih.gov/pubmed/31831761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55194-8
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