Synthesis and preclinical validation of novel P2Y1 receptor ligands as a potent anti-prostate cancer agent

Purinergic receptor is a potential drug target for neuropathic pain, Alzheimer disease, and prostate cancer. Focusing on the structure-based ligand discovery, docking analysis on the crystal structure of P2Y(1) receptor (P2Y(1)R) with 923 derivatives of 1-indolinoalkyl 2-phenolic compound is perform...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Le, Hien Thi Thu, Rimpilainen, Tatu, Konda Mani, Saravanan, Murugesan, Akshaya, Yli-Harja, Olli, Candeias, Nuno R., Kandhavelu, Meenakshisundaram
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908675/
https://ncbi.nlm.nih.gov/pubmed/31831761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55194-8
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