Bronchial epithelium repair by Esculentin-1a-derived antimicrobial peptides: involvement of metalloproteinase-9 and interleukin-8, and evaluation of peptides’ immunogenicity

The airway epithelium is seriously damaged upon pulmonary Pseudomonas aeruginosa infection, especially in cystic fibrosis (CF) sufferers. Therefore, the discovery of novel anti-infective agents accelerating healing of infected injured tissues is crucial. The antipseudomonal peptides esculentin-1a(1–...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Cappiello, Floriana, Ranieri, Danilo, Carnicelli, Veronica, Casciaro, Bruno, Chen, Han-Tang, Ferrera, Loretta, Di, Y. Peter, Mangoni, Maria Luisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908641/
https://ncbi.nlm.nih.gov/pubmed/31831857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55426-x
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