Inhibition of tRNA Gene Transcription by the Immunosuppressant Mycophenolic Acid

Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, a drug that is widely used for immunosuppression in organ transplantation and autoimmune diseases, as well as anticancer chemotherapy. It inhibits IMP dehydrogenase, a rate-limiting enzyme in de novo synthesis of guanidine nu...

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Publicat a:Mol Cell Biol
Autors principals: Jurkiewicz, Aneta, Leśniewska, Ewa, Cieśla, Małgorzata, Gorjão, Neuton, Kantidakis, Theodoros, White, Robert J., Boguta, Magdalena, Graczyk, Damian
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908259/
https://ncbi.nlm.nih.gov/pubmed/31658995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00294-19
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