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Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation

Members of the Fanconi anemia (FA) protein family are involved in multiple cellular processes including response to DNA damage and oxidative stress. Here we show that a major FA protein, Fancd2, plays a role in mitochondrial biosynthesis through regulation of mitochondrial translation. Fancd2 intera...

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Publicat a:Stem Cell Res
Autors principals: Chatla, Srinivas, Du, Wei, Wilson, Andrew F., Ruhikanta Meetei, Amom, Pang, Qishen
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907690/
https://ncbi.nlm.nih.gov/pubmed/31472450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2019.101550
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