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Intra-articular Injection of Chloramphenicol Reduces Articular Cartilage Degeneration in a Rabbit Model of Osteoarthritis

BACKGROUND: Osteoarthritis (OA) is characterized by degeneration of articular cartilage. Studies have found that enhancement of autophagy, an intracellular catabolic process, may limit the pathologic progression of OA. Chloramphenicol is a potent activator of autophagy; however, the effects of chlor...

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Détails bibliographiques
Publié dans:Clin Orthop Relat Res
Auteurs principaux: Wu, Xiaoqing, Cai, Yongsong, Lu, Shemin, Xu, Ke, Shi, Xuanren, Yang, Le, Huang, Zhenjian, Xu, Peng
Format: Artigo
Langue:Inglês
Publié: Wolters Kluwer 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907289/
https://ncbi.nlm.nih.gov/pubmed/31764352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CORR.0000000000001016
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