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De novo biosynthesis of 8-hydroxyoctanoic acid via a medium-chain length specific fatty acid synthase and cytochrome P450 in Saccharomyces cerevisiae

Terminally hydroxylated fatty acids or dicarboxylic acids are industrially relevant compounds with broad applications. Here, we present the proof of principle for the de novo biosynthesis of 8-hydroxyoctanoic acid from glucose and ethanol in the yeast Saccharomyces cerevisiae. Toxicity tests with me...

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Detalhes bibliográficos
Publicado no:Metab Eng Commun
Main Authors: Wernig, Florian, Boles, Eckhard, Oreb, Mislav
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906673/
https://ncbi.nlm.nih.gov/pubmed/31867212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mec.2019.e00111
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