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De novo biosynthesis of 8-hydroxyoctanoic acid via a medium-chain length specific fatty acid synthase and cytochrome P450 in Saccharomyces cerevisiae

Terminally hydroxylated fatty acids or dicarboxylic acids are industrially relevant compounds with broad applications. Here, we present the proof of principle for the de novo biosynthesis of 8-hydroxyoctanoic acid from glucose and ethanol in the yeast Saccharomyces cerevisiae. Toxicity tests with me...

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Vydáno v:Metab Eng Commun
Hlavní autoři: Wernig, Florian, Boles, Eckhard, Oreb, Mislav
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906673/
https://ncbi.nlm.nih.gov/pubmed/31867212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mec.2019.e00111
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