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Improving the odds of drug development success through human genomics: modelling study
Lack of efficacy in the intended disease indication is the major cause of clinical phase drug development failure. Explanations could include the poor external validity of pre-clinical (cell, tissue, and animal) models of human disease and the high false discovery rate (FDR) in preclinical science....
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6906499/ https://ncbi.nlm.nih.gov/pubmed/31827124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54849-w |
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