Improving the odds of drug development success through human genomics: modelling study

Lack of efficacy in the intended disease indication is the major cause of clinical phase drug development failure. Explanations could include the poor external validity of pre-clinical (cell, tissue, and animal) models of human disease and the high false discovery rate (FDR) in preclinical science....

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Vydáno v:Sci Rep
Hlavní autoři: Hingorani, Aroon D., Kuan, Valerie, Finan, Chris, Kruger, Felix A., Gaulton, Anna, Chopade, Sandesh, Sofat, Reecha, MacAllister, Raymond J., Overington, John P., Hemingway, Harry, Denaxas, Spiros, Prieto, David, Casas, Juan Pablo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906499/
https://ncbi.nlm.nih.gov/pubmed/31827124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54849-w
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