VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC

NADPH oxidase (NOX) enzymes are involved in a various physiological and pathological processes such as platelet activation and inflammation. Interestingly, we found that the pan-NOX inhibitors VAS compounds (VAS2870 and its analog VAS3947) exerted a highly potent antiplatelet effect. Unlike VAS comp...

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Vydáno v:Sci Rep
Hlavní autoři: Lu, Wan Jung, Li, Jiun Yi, Chen, Ray Jade, Huang, Li Ting, Lee, Tzu Yin, Lin, Kuan Hung
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906488/
https://ncbi.nlm.nih.gov/pubmed/31827142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55189-5
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