High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

Respiratory complex I is a redox-driven proton pump, accounting for a large part of the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Complex I dysfunction is associated with severe human diseases. Assembly of the one-megadalton complex I in the inner mitochond...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Parey, Kristian, Haapanen, Outi, Sharma, Vivek, Köfeler, Harald, Züllig, Thomas, Prinz, Simone, Siegmund, Karin, Wittig, Ilka, Mills, Deryck J., Vonck, Janet, Kühlbrandt, Werner, Zickermann, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905873/
https://ncbi.nlm.nih.gov/pubmed/31844670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax9484
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