MiR-23~27~24–mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation

Follicular helper T (T(FH)) cells are essential for generating protective humoral immunity. To date, microRNAs (miRNAs) have emerged as important players in regulating T(FH) cell biology. Here, we show that loss of miR-23~27~24 clusters in T cells resulted in elevated T(FH) cell frequencies upon dif...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Wu, Cheng-Jang, Cho, Sunglim, Huang, Hsi-Yuan, Lu, Chun-Hao, Russ, Jasmin, Cruz, Leilani O., da Cunha, Flavia Franco, Chen, Mei-Chi, Lin, Ling-Li, Warner, Lindsey M., Liao, Hsin-Kai, Utzschneider, Daniel T., Quon, Sara, Berner, Jacqueline, Camara, Niels Olsen Saraiva, Zehn, Dietmar, Belmonte, Juan Carlos Izpisua, Chen, Li-Chen, Huang, Shiang-Fu, Kuo, Ming-Ling, Lu, Li-Fan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2019
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905868/
https://ncbi.nlm.nih.gov/pubmed/31844658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw1715
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