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Identification of the hyaluronic acid pathway as a therapeutic target for facioscapulohumeral muscular dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) is linked to epigenetic derepression of the germline/embryonic transcription factor DUX4 in skeletal muscle. However, the etiology of muscle pathology is not fully understood, as DUX4 misexpression is not tightly correlated with disease severity. Using a...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: DeSimone, Alec M., Leszyk, John, Wagner, Kathryn, Emerson, Charles P.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905861/
https://ncbi.nlm.nih.gov/pubmed/31844661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw7099
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