Plasma concentration of neurofilament light chain protein decreases after switching from tenofovir disoproxil fumarate to tenofovir alafenamide fumarate

BACKGROUND: Because tenofovir alafenamide (TAF) leads to significantly lower plasma tenofovir concentrations than tenofovir disoproxil fumarate (TDF) and is a stronger substrate for P-glycoprotein (P-gp) than TDF, TAF could lead to decreased central nervous system (CNS) tenofovir exposure than TDF....

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hermansson, Linn, Yilmaz, Aylin, Price, Richard W., Nilsson, Staffan, McCallister, Scott, Makadzange, Tariro, Das, Moupali, Zetterberg, Henrik, Blennow, Kaj, Gisslen, Magnus
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905536/
https://ncbi.nlm.nih.gov/pubmed/31826005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226276
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