The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant

One of the most common mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene is the N34S variant which is strongly associated with chronic pancreatitis. Although it is assumed that N34S mutation constitutes a high-risk factor, the underlying pathologic mechanism is still unknown. In...

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Bibliografiska uppgifter
I publikationen:Biochim Biophys Acta Proteins Proteom
Huvudupphovsmän: Buchholz, Ina, Nagel, Felix, Klein, Annelie, Wagh, Preshit R., Mahajan, Ujjwal M., Greinacher, Andreas, Lerch, Markus M., Mayerle, Julia, Delcea, Mihaela
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905150/
https://ncbi.nlm.nih.gov/pubmed/31525466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2019.140281
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