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Early decrease in basophil sensitivity to Ara h 2 precedes sustained unresponsiveness after peanut oral immunotherapy

BACKGROUND: Only some peanut-allergic subjects undergoing oral immunotherapy (OIT) achieve sustained clinical response. Basophil activation could provide a functional surrogate of efficacy. OBJECTIVE: We hypothesized that changes in basophil sensitivity and AUC to the immunodominant allergen Ara h 2...

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Vydáno v:	J Allergy Clin Immunol
Hlavní autoři:	Patil, Sarita U., Steinbrecher, Johanna, Calatroni, Agustin, Smith, Neal, Ma, Alex, Ruiter, Bert, Virkud, Yamini, Schneider, Michael, Shreffler, Wayne G.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2019
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6905043/ https://ncbi.nlm.nih.gov/pubmed/31377342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.07.028
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Early decrease in basophil sensitivity to Ara h 2 precedes sustained unresponsiveness after peanut oral immunotherapy

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