Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage

Plasmodium gene functions in mosquito and liver stages remain poorly characterized due to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed more than 1,300 barcoded P. berghei mutants through the life cycle. We discover 461 genes required for efficient paras...

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Veröffentlicht in:Cell
Hauptverfasser: Stanway, Rebecca R., Bushell, Ellen, Chiappino-Pepe, Anush, Roques, Magali, Sanderson, Theo, Franke-Fayard, Blandine, Caldelari, Reto, Golomingi, Murielle, Nyonda, Mary, Pandey, Vikash, Schwach, Frank, Chevalley, Séverine, Ramesar, Jai, Metcalf, Tom, Herd, Colin, Burda, Paul-Christian, Rayner, Julian C., Soldati-Favre, Dominique, Janse, Chris J., Hatzimanikatis, Vassily, Billker, Oliver, Heussler, Volker T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904910/
https://ncbi.nlm.nih.gov/pubmed/31730853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.10.030
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