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Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks

Novel antimalarial therapies are urgently needed for the fight against drug-resistant parasites. The metabolism of malaria parasites in infected cells is an attractive source of drug targets but is rather complex. Computational methods can handle this complexity and allow integrative analyses of cel...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS Comput Biol
Main Authors: Chiappino-Pepe, Anush, Tymoshenko, Stepan, Ataman, Meriç, Soldati-Favre, Dominique, Hatzimanikatis, Vassily
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363809/
https://ncbi.nlm.nih.gov/pubmed/28333921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005397
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