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Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks

Novel antimalarial therapies are urgently needed for the fight against drug-resistant parasites. The metabolism of malaria parasites in infected cells is an attractive source of drug targets but is rather complex. Computational methods can handle this complexity and allow integrative analyses of cel...

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Bibliografiset tiedot
Julkaisussa:PLoS Comput Biol
Päätekijät: Chiappino-Pepe, Anush, Tymoshenko, Stepan, Ataman, Meriç, Soldati-Favre, Dominique, Hatzimanikatis, Vassily
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363809/
https://ncbi.nlm.nih.gov/pubmed/28333921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005397
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