Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake

In Brazil, cutaneous leishmaniasis is caused predominantly by L. (V.) braziliensis. The few therapeutic drugs available exhibit several limitations, mainly related to drug toxicity and reduced efficacy in some regions. Miltefosine (MF), the only oral drug available for leishmaniasis treatment, is no...

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Detalhes bibliográficos
Publicado no:Int J Parasitol Drugs Drug Resist
Main Authors: Espada, Caroline R., Magalhães, Rubens M., Cruz, Mario C., Machado, Paulo R., Schriefer, Albert, Carvalho, Edgar M., Hornillos, Valentín, Alves, João M., Cruz, Angela K., Coelho, Adriano C., Uliana, Silvia R.B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Includes articles from the special issue “Novel therapies for cutaneous leishmaniasis”, pp. 106 - 179
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904789/
https://ncbi.nlm.nih.gov/pubmed/30850347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2019.02.005
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