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Combined in silico and (19)F NMR analysis of 5-fluorouracil metabolism in yeast at low ATP conditions
The cytotoxic effect of 5-fluorouracil (5-FU) on yeast cells is thought to be mainly via a misincorporation of fluoropyrimidines into both RNA and DNA, not only DNA damage via inhibition of thymidylate synthase (TYMS) by fluorodeoxyuridine monophosphate (FdUMP). However, some studies on Saccharomyce...
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| Publicat a: | Biosci Rep |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Portland Press Ltd.
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6904775/ https://ncbi.nlm.nih.gov/pubmed/31742586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20192847 |
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