Combined in silico and (19)F NMR analysis of 5-fluorouracil metabolism in yeast at low ATP conditions

The cytotoxic effect of 5-fluorouracil (5-FU) on yeast cells is thought to be mainly via a misincorporation of fluoropyrimidines into both RNA and DNA, not only DNA damage via inhibition of thymidylate synthase (TYMS) by fluorodeoxyuridine monophosphate (FdUMP). However, some studies on Saccharomyce...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Pawłowski, Piotr H., Szczęsny, Paweł, Rempoła, Bożenna, Poznańska, Anna, Poznański, Jarosław
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2019
Assuntos:
Computational Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904775/
https://ncbi.nlm.nih.gov/pubmed/31742586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20192847
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados