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Cross-reactivity to Kynureninase Tolerizes B Cells that Express the HIV-1 Broadly Neutralizing Antibody 2F5
2F5 is an HIV-1 broadly neutralizing antibody (bnAb) that also binds the autoantigens kynureninase and anionic lipids. Generation of 2F5-like Abs is proscribed by immune tolerance, but it is unclear which auto-specificity is responsible. We sampled the BCR repertoire of 2F5 knock-in mice before and...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6904439/ https://ncbi.nlm.nih.gov/pubmed/31732530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900069 |
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