Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease

The MHC region is highly associated with autoimmune and infectious diseases. Here we conduct an in-depth interrogation of associations between genetic variation, gene expression and disease. We create a comprehensive map of regulatory variation in the MHC region using WGS from 419 individuals to cal...

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Udgivet i:eLife
Main Authors: D'Antonio, Matteo, Reyna, Joaquin, Jakubosky, David, Donovan, Margaret KR, Bonder, Marc-Jan, Matsui, Hiroko, Stegle, Oliver, Nariai, Naoki, D'Antonio-Chronowska, Agnieszka, Frazer, Kelly A
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Computational and Systems Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904215/
https://ncbi.nlm.nih.gov/pubmed/31746734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48476
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