Insights into the mutational burden of human induced pluripotent stem cells from an integrative omics approach

To understand the mutational burden of human induced pluripotent stem cells (iPSCs), we whole genome sequenced 18 fibroblast-derived iPSC lines and identified different classes of somatic mutations based on structure, origin and frequency. Copy number alterations affected 295 kb in each sample and s...

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Pubblicato in:Cell Rep
Autori principali: D’Antonio, Matteo, Benaglio, Paola, Jakubosky, David, Greenwald, William W., Matsui, Hiroko, Donovan, Margaret K. R., Li, He, Smith, Erin N., D’Antonio-Chronowska, Agnieszka, Frazer, Kelly A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467479/
https://ncbi.nlm.nih.gov/pubmed/30044985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.091
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