Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression

While genetic variation at chromatin loops is relevant for human disease, the relationships between contact propensity (the probability that loci at loops physically interact), genetics, and gene regulation are unclear. We quantitatively interrogate these relationships by comparing Hi-C and molecula...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Greenwald, William W., Li, He, Benaglio, Paola, Jakubosky, David, Matsui, Hiroko, Schmitt, Anthony, Selvaraj, Siddarth, D’Antonio, Matteo, D’Antonio-Chronowska, Agnieszka, Smith, Erin N., Frazer, Kelly A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401380/
https://ncbi.nlm.nih.gov/pubmed/30837461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08940-5
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