Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk

BACKGROUND: Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα), which leads to cachexia in mice and is associat...

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Опубликовано в: :J Cachexia Sarcopenia Muscle
Главные авторы: Wu, Jiao, Dong, Jiangling, Verzola, Daniela, Hruska, Keith, Garibotto, Giacomo, Hu, Zhaoyong, Mitch, William E., Thomas, Sandhya S.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6903446/
https://ncbi.nlm.nih.gov/pubmed/31507080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12459
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