Charting cellular identity during human in vitro β-cell differentiation

In vitro differentiation of human stem cells can produce pancreatic β cells; the loss of this insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding this differentiation process, we report the transcriptional profiling of over 100,000 human cells undergoing in v...

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Udgivet i:Nature
Main Authors: Veres, Adrian, Faust, Aubrey L., Bushnell, Henry L., Engquist, Elise N., Kenty, Jennifer Hyoje-Ryu, Harb, George, Poh, Yeh-Chuin, Sintov, Elad, Gürtler, Mads, Pagliuca, Felicia W., Peterson, Quinn P., Melton, Douglas A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6903417/
https://ncbi.nlm.nih.gov/pubmed/31068696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1168-5
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