Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis

Diabetes mellitus (DM) affects bone metabolism and leads to osteoporosis; however, its pathogenetic mechanisms remain unknown. We found that high glucose (HG) conditions induced the production of reactive oxygen species (ROS) and the expression of proteins related to MAPKs [phosphorylated (p)-ERK, p...

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Publicat a:FASEB J
Autors principals: An, Yanan, Zhang, Haifeng, Wang, Chao, Jiao, Fangtai, Xu, Hongyue, Wang, Xuefei, Luan, Wenjing, Ma, Fangxue, Ni, Lihui, Tang, Xudong, Liu, Mingyuan, Guo, Weiying, Yu, Lu
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902677/
https://ncbi.nlm.nih.gov/pubmed/31461386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802805RR
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