Catalytically inactive receptor tyrosine kinase PTK7 activates FGFR1 independent of FGF

Protein tyrosine kinase 7 (PTK7), a catalytically defective receptor protein tyrosine kinase (RPTK), plays an oncogenic role by activating an unidentified TKI-258 (dovitinib)-sensitive RPTK in esophageal squamous cell carcinoma (ESCC) cells. Here, we demonstrate that among TKI-258–sensitive RPTKs, f...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Shin, Won-Sik, Lee, Hae Won, Lee, Seung-Taek
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902674/
https://ncbi.nlm.nih.gov/pubmed/31490704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900932R
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