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Editorial focus: understanding off-target effects as the key to successful RNAi therapy

With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we witness the RNAi therapy field reaching a critical turning point, when further improvements in drug candidate design and delivery pipelines should enable fast delivery of novel life changing treatments to patients....

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Pubblicato in:Cell Mol Biol Lett
Autori principali: Bartoszewski, Rafal, Sikorski, Aleksander F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902517/
https://ncbi.nlm.nih.gov/pubmed/31867046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s11658-019-0196-3
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