Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation

Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLRP3 inflammasome activation was demonstrated by a d...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Darweesh, Mahmoud, Kamel, Wael, Gavrilin, Mikhail A., Akusjärvi, Göran, Svensson, Catharina
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901988/
https://ncbi.nlm.nih.gov/pubmed/31849970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02791
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