Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia

Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and SIRT3 target proteins involved in metabolic, proliferation and inflammation pathways and have been implicated in the pathogenesis of neurodegenerative, metabolic and oncologic disorders. Both pro- and...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Heinonen, Tytti, Ciarlo, Eleonora, Rigoni, Ersilia, Regina, Jean, Le Roy, Didier, Roger, Thierry
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901967/
https://ncbi.nlm.nih.gov/pubmed/31849939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02713
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