Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 deficiency has been reported to promote chronic inflammation-rel...

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Vydáno v:Sci Rep
Hlavní autoři: Ciarlo, Eleonora, Heinonen, Tytti, Lugrin, Jérôme, Acha-Orbea, Hans, Le Roy, Didier, Auwerx, Johan, Roger, Thierry
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478639/
https://ncbi.nlm.nih.gov/pubmed/28634345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04263-x
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