Efficient Pre-catalytic Conformational Change of Reverse Transcriptases from SAMHD1 Non-counteracting Primate Lentiviruses During dNTP Incorporation

Unlike HIV-1, HIV-2 and some SIV strains replicate at high dNTP concentrations even in macrophages due to their accessory proteins, Vpx or Vpr, that target SAMHD1 dNTPaSe for proteasomal degradation. We previously reported that HIV-1 reverse transcriptase (RT) efficiently synthesizes DNA even at low...

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Bibliographische Detailangaben
Veröffentlicht in:Virology
Hauptverfasser: Coggins, Si’Ana A., Holler, Jessica M., Kimata, Jason T., Kim, Dong-Hyun, Schinazi, Raymond F., Kim, Baek
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901729/
https://ncbi.nlm.nih.gov/pubmed/31442614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.08.010
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