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Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery
Most lysosomal storage disorders affect the central nervous system. However, lysosomal enzymes do not cross the blood-brain barrier (BBB), and intravenous enzyme infusion is not effective for the brain. Lysosomal enzymes can be re-engineered for BBB transport as IgG-enzyme fusion proteins, where the...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6901507/ https://ncbi.nlm.nih.gov/pubmed/31819150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55136-4 |
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