A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity

Cytokine macrophage migration inhibitory factor-2 (MIF-2 or D-dopachrome tautomerase) is a recently characterized second member of the MIF cytokine superfamily in mammalian genomes. MIF-2 shares pro-inflammatory and tumorigenic properties with the clinical target MIF (MIF-1), but the precise contrib...

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Publicado en:J Biol Chem
Autores principales: Tilstam, Pathricia Veronica, Pantouris, Georgios, Corman, Michael, Andreoli, Monica, Mahboubi, Keyvan, Davis, Gary, Du, Xin, Leng, Lin, Lolis, Elias, Bucala, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901300/
https://ncbi.nlm.nih.gov/pubmed/31578280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009860
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